Lifestyle Change for Better Health Study

STUDY BASICS

Did you have bladder cancer that was completely surgically removed? Are you 18-84 years old? If so, you may be able to take part in a research study investigating how lifestyle changes affect weight, fitness level, quality of life, and certain biomarkers in people with a history of non-metastatic bladder cancer (BC). Compensation provided.

STUDY PURPOSE

Bladder cancer is one of the most commonly diagnosed cancers in the United States. People with non-metastatic bladder cancer (BC) can often have their cancer completely removed through surgery, but there is a chance that the cancer will come back. Some studies have shown that excess body weight and low levels of physical activity increase the risk that bladder cancer will return. The purpose of this research study is to find out how diet and exercise programs affect weight, activity levels, quality of life, and biomarkers in people with a history of non-metastatic BC. Biomarkers, or biological markers, are measurable substances in bodily fluids or tissues that can provide information about the body and may signal the presence of a condition or disease. Researchers hope their findings will lead to new ways to treat people with non-metastatic BC and reduce the risk of bladder cancer recurrence in the future.

COULD THIS STUDY BE RIGHT FOR YOU?

• Ages 18-84
• History of non-metastatic bladder cancer, under surveillance with no current sign of disease
• BMI (body mass index) of at least 25 but less than 40

WHAT PARTICIPANTS CAN EXPECT

After we determine that you are eligible to participate, you will be randomly assigned (like the flip of a coin) to one of two weight control programs. One program includes an exercise component (walking), while the other does not. Both programs are 6 months long and involve being placed on a diet, meetings in-person and over the phone, and study assessments taken before, during, and after the weight control program. These assessments include self-report forms, questionnaires, urine and blood samples, and physical measurements (body weight, blood pressure, fitness levels, etc.). Your active participation in the study will last about 6 months, followed by a blood draw 12 months after joining the study, and yearly review of your medical records for up to 4 years.