ADAPTABLE Study

STUDY BASICS

Have you been diagnosed with heart disease? You may be able to participate in a research study to help find out which dose of aspirin is best at preventing heart attacks and strokes in people with heart disease. Participation involves being randomly assigned to take either regular aspirin (325 mg) or low-dose aspirin (81 mg) for up to 3 years. Compensation provided.

STUDY PURPOSE

For more than 40 years, doctors have advised patients with heart disease to take aspirin to lower their risk of heart attacks and strokes. Millions of Americans who have heart disease already take either regular (325 mg) or low-dose (81 mg) aspirin. Many studies have shown that both doses work and both are generally safe, but no one knows which dose is better. The purpose of this study is to help researchers find out which dose of aspirin is better at preventing heart attacks and strokes while minimizing potential side effects in people with heart disease. Researchers hope their findings will lead to better treatments for people who have heart disease in the future.

COULD THIS STUDY BE RIGHT FOR YOU?

• Age 18 and up
• Diagnosed with heart disease (for example, prior heart attack, coronary artery disease, atherosclerosis, and others)
• May or may not currently be taking aspirin therapy to reduce risk of heart disease
• No problems taking aspirin in the past
• Not currently taking a blood thinner (such as warfarin or Coumadin®)
• Not pregnant or planning on becoming pregnant during the study time period
• Have access to an Internet-connected computer, tablet, or smartphone

WHAT PARTICIPANTS CAN EXPECT

All study participation takes place online; there are no in-person study visits. Participation involves answering a few questions about you and your health to be sure you are a good fit for this study. Qualified participants will be randomly assigned (like the flip of a coin) to take either a regular dose of aspirin (325 mg) or a low-dose aspirin (81 mg) daily for up to 3 years. Please note that participants will need to buy the assigned dose of aspirin and take it daily. Every 3-6 months while you are in the study, you will be asked to complete short online surveys that will take about 15 minutes each. The study team will also ask your permission to obtain certain information from your medical records.