Constellation Depression Neuroimaging Study

STUDY BASICS

Are you 18-60 years old? Do you often feel down, low, or depressed? You may be able to participate in a research study to help better understand brain changes that occur over time in people with depression. Participation includes interviews, questionnaires, behavioral/computer tasks, brain scanning, and, for some participants, an optional ketamine infusion. Compensation provided.

STUDY PURPOSE

Depression is a common mental health disorder associated with symptoms such as feeling sad or hopeless, feeling tired or not having energy, loss of interest in hobbies and activities, and changes in sleep and appetite. Current treatments can help some people with depression manage their symptoms, but they do not work for everyone.

 

The purpose of this research study is to learn more about brain changes that occur over time in people with depression. Researchers hope their findings lead to better treatments for depression in the future.

COULD THIS STUDY BE RIGHT FOR YOU?

• Ages 18-60
• Often feel down, low, or depressed
• No history of bipolar depression or autism
• Able and willing to undergo MRI scanning
• Not currently taking any psychiatric medications

WHAT PARTICIPANTS CAN EXPECT

Over a 5-week period, participants will complete 3 visits that include interviews, questionnaires, behavioral/computer tasks, and functional MRI and EEG scans of the brain.

Following these procedures, participants receive an infusion of intravenous ketamine, followed by additional assessments of the brain, behavior, and symptoms over an additional 2-3 week period.”