Are you a healthy African American adult aged 20-59? If so, you may be eligible to participate in a research study to help learn more about the impact of stress on DNA damage and repair. Compensation provided.
Most people experience stress from time to time due to concerns about family, health, relationships, or work. Some research suggests that stress can damage a person’s DNA—the material in each cell that allows the body to function. Although the body is typically able to repair DNA damage, repeated occurrences of DNA damage and repair may increase a person’s risk for developing certain health problems over time.
The purpose of this study is to better understand the impact of brief stress on DNA damage and repair. Researchers also want to find out if physical, lifestyle, and behavioral factors are related to differences in stress responses, and if those responses can be changed by taking a single dose of a commonly-used high blood pressure medication called propranolol. Researchers hope their findings may lead to new ways to prevent DNA damage in the future.
COULD THIS STUDY BE RIGHT FOR YOU?
• Ages 20-59
• African American
• Weigh at least 110 pounds
• Have not used illicit drugs, smoked cigarettes, or used other nicotine-containing products in the past month
• Have never been diagnosed with cancer (other than basal cell skin cancer), COPD, heart disease, high blood pressure, multiple sclerosis (MS), or severe traumatic brain injury
• Not currently diagnosed with asthma, diabetes, major depression, bipolar depression, an anxiety disorder, or schizophrenia
• If female, have not been pregnant or breastfeeding for the past 3 months, have regular menstrual periods (21-35 days) or are post-menopausal, and are not taking any medications that prevent you from having monthly menstrual cycles (birth control shot, IUD, “seasonal” birth control)
WHAT PARTICIPANTS CAN EXPECT
Participation involves an initial phone call to find out if you may be eligible to participate in the study. If eligible after the telephone call, you will be scheduled for a screening visit that will include a brief health assessment, urine tests, blood work, and a set of psychological interviews. Participants who are still eligible after the screening visit will complete several questionnaires and attend two more study visits. During the study visits, participants will complete additional questionnaires, provide blood and saliva samples, and complete tasks. At the first visit, participants will be randomly assigned (like the flip of a coin) to receive either a single dose of propranolol (a beta blocker commonly used to treat high blood pressure) or placebo (an inactive medication).
IRB:STUDY19040308 - Brief stresses and DNA integrity: An experimental analysis
DURATION: Up to 6 months
VISITS: 3 visits
UPMC Hillman Cancer Center – Oakland
Up to $205 + parking/ travel reimbursement