iCARE Study – Participants Ages 18-21 and Parent or Grandparent with Cancer Diagnosis
STUDY BASICS
Are you between 18-21 years old? Do you have a parent or grandparent who has been recently diagnosed with cancer? Families are needed for a research study to help learn more about how stress from a parent or grandparent’s cancer diagnosis affects children. Compensation is provided.
STUDY PURPOSE
Experiencing stress during young adulthood can lead to physical and mental changes. In some cases, stress can contribute to the development of depression, post-traumatic stress disorder (PTSD), and suicidal thoughts. Researchers do not fully understand why some people who experience stress go on to develop mental illness and others do not. The purpose of this study is to better understand how stress from a parent or grandparent’s cancer diagnosis affects the biological, emotional, and behavioral well-being of young adults. Researchers hope their findings will lead to better ways to prevent and treat mental illness brought on by stress.
COULD THIS STUDY BE RIGHT FOR YOU?
- Ages 18-21
- Parent or grandparent diagnosed with cancer
- Have not been diagnosed with Cushing’s syndrome or Addison’s disease
- Not pregnant
WHAT PARTICIPANTS CAN EXPECT
Participation involves an initial visit, and two follow up visits at 6 and 18 months. You will be asked to complete an interview and questionnaires, provide blood, hair, and saliva samples, have blood pressure and heart rate assessed, and have physical measurements.
IRB: STUDY19110085E
- Biomarkers in the HPA axis and inflammatory pathways for maladaptive stress response in childrenMEET THE RESEARCHER

Nadine Melhem
Nadine M. Melhem, PhD, MPH, is associate professor of psychiatry at the University of Pittsburgh School of Medicine. Trained in psychiatric genetic epidemiology, Dr. Melhem has a long history of working in research and a special interest in studying the impacts of stress and trauma on children and families.