KAPNI: Ketamine and Propofol NeuroImaging

STUDY BASICS

Healthy adults who are fluent in English, age 18-59, are being recruited to better determine the effect that anesthetic agents have on memory formation. There are eight visits associated with participation in this research study: two EEG and two fMRI sessions will last approximately 3-4 hours each and four follow-up visits. Compensation is provided.

STUDY PURPOSE

The purpose of this study is to better understand what factors allow or prevent memories to be formed in people receiving intravenous anesthesia and experiencing pain. Knowing this may improve the ability to control pain and prevent unpleasant memories during medical procedures, using nitrous oxide anesthesia.

COULD THIS STUDY BE RIGHT FOR YOU?

• are 18-59 years old
• are not pregnant or attempting to conceive
• have a body mass index (BMI) < 35
• do not have significant memory impairment or hearing loss
• do not have sleep apnea
• do not have chronic pain or other pain processing disorder
• do not have neurologic or psychiatric conditions, including seizures, tremor, anxiety, or depression
• do not have chronic medical conditions
• are not claustrophobic
• have no metal implants, and no non-removable metal piercings
• have no history of adverse reaction to anesthetics
• are not an active smoker
• have no history of illicit substance abuse
• are not taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, sleep-aids, or pain medication

WHAT PARTICIPANTS CAN EXPECT

There are eight visits associated with participation in this study. Two EEG and two fMRI sessions will last approximately 3-4 hours each. Four follow-up visits, each one day after the EEG and fMRI sessions, must take place the next day and will last approximately 1 hour.