Achilles Tendinopathy Study

STUDY BASICS

Do you suffer from Achilles tendinopathy pain? If so, you may be eligible for a research study examining the effectiveness of metformin on the management of tendon inflammation and pain. Participation includes three separate visits over a period of 16 weeks. Compensation is provided.

STUDY PURPOSE

Investigators associated with the Departments of Orthopaedic Surgery and Physical Medicine and Rehabilitation at the University of Pittsburgh are conducting an exploratory clinical trial to test the effectiveness of metformin as a treatment for chronic Achilles tendinopathy.  Metformin is an FDA-approved drug for the treatment of type II diabetes and is not currently approved by the FDA for the treatment of Achilles tendinopathy. This research study is investigating the use of Metformin or placebo combined with a home exercise program.

COULD THIS STUDY BE RIGHT FOR YOU?

• 18-60 years of age
• Achilles tendon pain for a minimum of six months
• Ability to read, speak, and understand English
• Have not undergone any other interventions (corticosteroids or other orthobiologic injections) to the Achilles tendon in the last 6 months

WHAT PARTICIPANTS CAN EXPECT

• 3 separate in-clinic visits
• An oral dose of metformin tablets or placebo for 16 weeks
• Ultrasound of the Achilles tendon
• Questionnaires
• Strength and endurance tests