Addressing Cognitive Fog in Long-COVID Patients

STUDY BASICS

Are you 21 to 65 years old? Have you had COVID symptoms lasting 3 months or longer after infection? You may be eligible for a research study to determine best treatment options for Long-COVID patients with cognitive impairment. Compensation provided.

STUDY PURPOSE

The UPMC Post-COVID Recovery clinic serves the clinical needs of Long-COVID patients, defined as people with post-COVID conditions or symptoms lasting more than four weeks after infection. To date, characterization (phenotyping) of over 150 Long-COVID patients show 86% with new onset cognitive fog (using validated criteria) and 48% with depression (PHQ8 criteria). Cognitive fog was the most common complaint endorsed by patients during their clinic evaluations. Additionally, a subgroup of patients requesting a behavioral evaluation, who were in the prime of their adult productivity, reported that “cognitive fog” was the main symptom impacting their functioning, work performance, and life satisfaction; making it a critical area to target clinically. The specific cognitive deficits reported as part of this “fog” varied across patients. This study is being completed to determine best treatment options for Long-COVID patients with cognitive impairment.

COULD THIS STUDY BE RIGHT FOR YOU?

• Age 21-65 years old
• Have cognitive deficits associated with Long-COVID

WHAT PARTICIPANTS CAN EXPECT

If you are eligible and agree to enroll in this study, you will be randomized to one of two acceptable interventions for treating cognitive fog.