Tension, Anxiety & Brain Imaging (TABI) study

STUDY BASICS

Do you feel sad or depressed? Are you 30-50 years old? Do you work at least 20 hours per week? If so, you may be eligible to participate in a research study to help learn more about how the brain functions when people with depression experience stress. Compensation provided.

STUDY PURPOSE

Many people with depression find it difficult to perform their normal daily activities at home or in the workplace. Research suggests that for some people with depression, experiencing stress can have a negative effect on brain function, but this relationship is not fully understood. Although the relationship between stress and brain function in depressed people is not fully understood, researchers suspect that impaired brain function may make it more difficult for some people to return to their normal daily activities. The purpose of this study is to help researchers learn more about how the brain functions when people with depression are experiencing stress. Researchers hope their findings will lead to better ways to treat depression in the future.

COULD THIS STUDY BE RIGHT FOR YOU?

• Ages 30-50
• Feeling sad or depressed
• Work at least 20 hours per week
• Not taking any stimulant medications, such as Adderall, Focalin, Adzenys XR-ODT, dexedrine, etc.
• No history of mania or psychosis
• No history of head trauma, seizures, or electroconvulsive therapy
• Not colorblind
• Do not abuse drugs or alcohol
• Willing and able to undergo MRI scanning (no non-removable metal in your body, not claustrophobic)
• Not pregnant or planning to become pregnant in the next 3 months

WHAT PARTICIPANTS CAN EXPECT

Participation in this study involves up to 3 visits, including an interview, 2 MRI brain scans, and a 2-week at-home smartphone diary study. MRI scans are not invasive and do not use radiation.