Bipolar Disorder Brain Imaging Study

STUDY BASICS

Have you been diagnosed with Bipolar I Disorder and are currently in remission (not symptomatic)? Are you between the ages of 18-45 and right-handed? If so, you may be able to participate in a brain imaging research study. Study involves interviews, questionnaires, and undergoing an fMRI scan while wearing a cap that sends mild levels of stimulation to the brain. Compensation provided.

STUDY PURPOSE

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in feelings of mood, energy, activity levels, and the ability to carry out day-to-day tasks (NIMH). Periods of time when people feel very “up” are called mania, and periods of time when people feel very “down” are called depression. People with bipolar disorder who are not currently having significant symptoms are said to be in remission. The purpose of this study is to use weak electrical brain stimulation and brain imaging scans to learn more about how the brain works in people with and without bipolar disorder. Researchers hope the results will lead to a better understanding of bipolar disorder symptoms, and to the development new therapies.

COULD THIS STUDY BE RIGHT FOR YOU?

• Ages 18-45
• Right-handed
• Diagnosed with Bipolar Disorder I, and currently in remission
• Willing and able to undergo MRI scan (no metal in the body, such as non-removable piercings, non-titanium pins/screws and not claustrophobic)
• No illegal drug use or alcohol abuse

WHAT PARTICIPANTS CAN EXPECT

Study participation involves three visits. The initial 1-3 hour screening visit includes a psychiatric interview, medical history, other tests and assessments, and a urine screen for controlled (illegal) substances. The two scanning visits will last 2-3 hours each, and will be scheduled on separate days approximately one week apart. During the scanning visits, participants will do computer tasks while a weak electrical stimulation called tDCS (transcranial Direct Current Stimulation) is applied to the scalp during a functional Magnetic Resonance (fMRI) scan. fMRI is a non-invasive imaging technique used to measure brain activity.