Adrenalectomy Followed by Tirzepatide for Managing Patients with Mild Autonomous Cortisol Secretion

STUDY BASICS

Having adrenal surgery? You may qualify for a research study. We are studying whether a weight loss medication (tirzepatide / Zepbound / Mounjaro) given after adrenal surgery improves blood pressure, weight, and blood sugar control.

STUDY PURPOSE

This study is to find out if adding a drug known as “Tirzepatide/Zepbound/Mounjaro” improves the treatment for people with Mild Autonomous Cortisol Secretion (MACS) who are having an adrenalectomy. 

COULD THIS STUDY BE RIGHT FOR YOU?

• Adrenal tumor with mild cortisol excess - Scheduled for adrenalectomy at UPMC

• Elevated blood pressure - Current hypertension or taking blood pressure medication

• BMI ≥ 27 - Overweight or obese by body mass index

WHAT PARTICIPANTS CAN EXPECT

•  No change to your surgery.

•  Randomized to 1 of 2 groups: surgery + tirzepatide injection, or surgery follow-up only

•  2 follow-up visits at 6 and 12 months, aligned with your routine post-op care

•  Reimbursement for travel expenses is provided