MATRIX Study: Modulating Activity with Transcranial Intervention for Exploration
STUDY BASICS
Are you 18 to 45 years of age? You may be eligible for a research study to find out how transcranial focused ultrasound (tFUS) influences brain structure and function in healthy adults. Participation involves 9-10 study visits over the course of about 6 months Compensation is provided.
STUDY PURPOSE
This study will examine the effects of noninvasive stimulation on brain activity as measured by functional magnetic resonance imaging (fMRI) in healthy young adults.
COULD THIS STUDY BE RIGHT FOR YOU?
- 18-45 years of age
- Normal or corrected to normal vision
- Right handed
- No history of Major Depressive Disorder, Psychosis, Bipolar Disorder, Borderline Personality Disorder, or Suicidal Ideation
- No history of head injuries or neurological conditions (such as epilepsy)
- No metal objects or surgical implants in your body
WHAT PARTICIPANTS CAN EXPECT
- answering questions about topics like your health history and feelings
- receiving brain stimulation from transcranial focused ultrasound (tFUS)
- taking pictures of your brain structure and function in CT (computerized tomography) and MRI scanners during rest and while doing a task
- taking urine drug and salivary alcohol tests
- taking urine pregnancy tests in participants with child bearing potential
- pushing buttons during computer tasks
IRB: STUDY24020142
- Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorderMEET THE RESEARCHER

Mary Phillips
Mary L. Phillips, MD, is Professor in Psychiatry and Translational Science and Director of the Mood and Brain Laboratory at the University of Pittsburgh. A graduate of the University of Cambridge, Dr. Phillips’ research focuses on the identification of neural correlates that underlie symptoms of specific abnormalities in emotion processing in people with mood disorders.