KINETIC Research Study

STUDY BASICS

Are you pregnant and plan to have a cesarean delivery (C-section) at UPMC Magee-Womens Hospital? If so, you may be able to participate in a research study to find out if ketamine is safe and effective for controlling pain after a C-section, and if ketamine given in this way is transferred into breast milk. Participation takes place in the hospital after you give birth. Compensation is provided.

STUDY PURPOSE

Ketamine is a non-opioid painkiller that is often used after surgery, but little is known about the effect of ketamine on women who have recently had a cesarean section (C-section). The purpose of this research study is to find out if a low dose of ketamine is safe and effective for controlling pain after a C-section, and if ketamine given in this way is transferred into breast milk. Researchers hope their findings lead to a reduction in the use of opioids and a better understanding of the role of ketamine in women who have recently given birth.

COULD THIS STUDY BE RIGHT FOR YOU?

• Women aged 18 and up
• Planning to have a cesarean delivery (C-section) at UPMC Magee-Womens Hospital
• Not planning to breastfeed, or are willing to withhold breastfeeding during the first 27 hours after birth

WHAT PARTICIPANTS CAN EXPECT

During your hospital stay, you will be given a 12-hour infusion of ketamine through your IV right after your baby is delivered. After the infusion ends, you will be monitored for 15 hours. During and after the infusion, you will be asked to provide breast milk, blood, and urine samples, and complete computerized surveys about pain and mood.