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Pitt+Me LOGIC Study for Adults with Cholestatic Liver Disease


STUDY BASICS

Do you have a diagnosed or suspected cholestatic liver disease? Adults between the ages of 18 and 25 may be able to participate in a research study to learn more about the causes and long-term effects of certain cholestatic liver diseases. Compensation provided.


STUDY PURPOSE

Cholestasis is a condition in which the flow of bile from the liver is slowed or blocked. Many different conditions and medications can lead to cholestasis and cholestatic liver disease. People with cholestatic liver disease can have symptoms that include digestive problems, itchy skin, and yellow skin or eyes.

The purpose of this study is to learn more about the causes and long-term effects of the following cholestatic liver diseases: Alagille syndrome, alpha-1-antitrypsin deficiency, progressive familial intrahepatic cholestasis and benign recurrent intrahepatic cholestasis, and bile acid synthesis defects.


COULD THIS STUDY BE RIGHT FOR YOU?

•    Ages 18-25
•    Have (or suspected to have) any of the following cholestatic liver diseases: Alagille syndrome, alpha-1-antitrypsin deficiency, progressive familial intrahepatic cholestasis or benign recurrent intrahepatic cholestasis, or bile acid synthesis defects


WHAT PARTICIPANTS CAN EXPECT

Medical record information and blood and urine samples will be collected for each participant. Parents may also be asked to provide blood samples. The information and samples will be stored in a database and used by researchers to learn more about these diseases.


IRB:
  STUDY19020201A - Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis


Age Range
AGE:   18 - 25

Duration DURATION:  10 years
VISITS:  1 visit per year

Location LOCATION: 
UPMC Children’s Hospital of Pittsburgh
Compensation COMPENSATION: 
$25 per visit
Phone Number PHONE NUMBER:
1-866-438-8230
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Phone Number PHONE NUMBER:
1-866-438-8230

MEET THE RESEARCHER


Robert Squires

Robert H. Squires, Jr., MD, is Professor of Pediatrics at the University of Pittsburgh School of Medicine, and is the Medical Director of Pediatric Liver Transplantation. As a gastroenterologist, Dr. Squires is an expert in diseases related to the digestive system, specializing in conditions that affect the liver. A dedicated and valued researcher, Dr. Squires has served the children of Pittsburgh for over a decade.




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