RADIANT

STUDY BASICS

Are you depressed and not receiving treatment? You may be eligible for a research study to look at brain mechanisms that lead to recovery from depression. The study involves multiple functional MRI and neuromodulation sessions. Compensation is provided.

STUDY PURPOSE

The RADIANT research study is designed to look at brain mechanisms that lead to recovery from depression.

COULD THIS STUDY BE RIGHT FOR YOU?

• are between the ages of 18 and 55
• are fluent in English
• have major depressive disorder
• are currently not receiving any medication, psychotherapy, electroconvulsive therapy (ECT) or Transcranial Magnetic Stimulation (TMS) for your depression

WHAT PARTICIPANTS CAN EXPECT

By participating in this study, you will complete 5 visits.

• Screening Visit: complete a clinical interview and several questionnaires.
• Visit 0: complete baseline structural and functional magnetic resonance image (fMRI) scans.
• Visits 1, 2, and 3: you will receive three sessions of:
  • Transcranial Magnetic Stimulation (TMS)
  • The intravenous administration of a fast-acting or a conventional antidepressant.
  • Functional magnetic resonance image (fMRI)
• A 1-week follow-up, where you will be asked to report on your mood symptoms after each experimental manipulation.