AsthmaNet – SIENA Study

STUDY BASICS

If you are a non-smoker with mild asthma and use a rescue inhaler, you may be able to participate in a research study. The goal of the study is to find out if there is a benefit to matching a person’s medication to the specific the type of inflammatory cells in their airway. Asthma medications and compensation provided.

STUDY PURPOSE

Most people with asthma have inflammation (swelling) in their airway. Asthma controller medications, like inhaled corticosteroids, are meant to reduce inflammation in the airway. Reducing airway inflammation should make breathing easier, but many people with asthma don’t breathe easier when they take an inhaled corticosteroid. Researchers know that there are several types of cells that can cause airway inflammation. However, inhaled corticosteroids mostly target only one type. The purpose of this research study is to find out if a person’s asthma medication should be matched to the specific type of inflammatory cells in their airway.

COULD THIS STUDY BE RIGHT FOR YOU?

• Diagnosed with mild asthma
• Use a rescue inhaler such as Albuterol, Proventil, Ventolin, ProAir or Xopenex
• Age 18 or older
• Non-smoker
• OR tobacco free for 1 year
• Not pregnant, breastfeeding or planning on becoming pregnant during the study period

WHAT PARTICIPANTS CAN EXPECT

To determine if you are able to participate, you will have 3 visits (2-3 hours each) and 2 phone calls over 4-6 weeks. You will give a sputum sample 2-3 times during those visits. If you qualify for the study, you will have 6 study visits and 6 brief phone calls over 36 weeks. Study visits take from 1 - 3 hours and may include a physical exam, blood draw, and breathing tests. If your asthma gets worse during the study, you may be asked to come in for one or more extra visits and will receive additional phone calls. Medications and tests will be provided at no cost.