REMAZ: Neuroimaging of sedation with Remimazolam

STUDY BASICS

Healthy adults who are fluent in English, age 18-59, are being recruited for a research study of the commonly-used anesthetic remimazolam. There are two visits associated with participation in this study. This involves MRI scans while performing a memory task and experiencing periodic painful electric shocks, at a level you set in advance. Compensation is provided.

STUDY PURPOSE

The purpose of this study is to better understand what factors allow or prevent memories to be formed in people receiving inhalational anesthesia and experiencing pain. Knowing this may improve the ability to control pain and prevent unpleasant memories during medical procedures, using remimazolam anesthesia.

COULD THIS STUDY BE RIGHT FOR YOU?

• are not pregnant or attempting to conceive
• are normal weight
• do not have significant memory impairment or hearing loss
• do not have sleep apnea
• do not have chronic pain or other pain disorder
• do not regularly take medicine for pain or sleep
• do not take anti-depressants (including SSRIs)
• are not a current smoker
• are able to undergo MRI (no metal or implants)
• have not had recent eye or ear surgery
• have no history of severe cardiac disease
• do not regularly use marijuana (prescription or recreational)
• have no significant history of using other recreational drugs

 

 

WHAT PARTICIPANTS CAN EXPECT

There are two visits associated with participation in this study. The first visit will last approximately 3-4 hours. The second visit must occur the next day and will last approximately 1 hour.