Reorganization of Neural Circuits Post Amputation

STUDY BASICS

Do you have a lower-limb amputation? Researchers at the University of Pittsburgh are recruiting subjects to perform simple experiments to understand reorganization in brain and spinal circuits post-amputation. Study participation will include 2-3 visits, each visit lasting up to four (2-4) hours. Compensation is provided.

STUDY PURPOSE

Information learned through this study will provide a better understanding for the reorganization of neural circuits in the brain and spinal cord post lower-limb amputation.  

COULD THIS STUDY BE RIGHT FOR YOU?

• Are between the ages of 22-70
• Have normal or corrected to normal vision (glasses or contacts are okay)
• Experienced traumatic unilateral lower-limb amputation
• Have no serious medical problems (including neurologic disease, motor impairment, or acute or chronic pain), and
• Do not have claustrophobia and metal or implanted devices in your body.

WHAT PARTICIPANTS CAN EXPECT

Study participation will include 2-3 visits, each visit lasting up to four (2-4) hours. Experiments will be conducted in Mercy Pavilion and UPMC Presby.  The study involves completing a simple questionnaire and experiments designed to provide a comparison for data collected from people using neuroprosthetic devices. This will include MRI and MEG scans while performing simple leg movements.