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Pitt+Me NOP Receptor Imaging in Alcoholism


STUDY BASICS

The University of Pittsburgh Departments of Radiology and Psychiatry are seeking adults ages 18-55 who have a problem with alcohol for a brain imaging research study. Participation involves questionnaires, interviews, and brain scanning (1 MRI, 1 CT, and 1 PET scan). Compensation provided.


STUDY PURPOSE

The purpose of this study is to help researchers understand the role of a protein called nociceptin/orphanin FQ in alcohol dependence. Nociceptin/orphanin FQ is used by the brain to pass messages between brain cells, and seems to play an important role in regulating pain, stress, and reward functions. To learn about the role of nociceptin/orphanin FQ in alcohol dependence, researchers will compare brain scans from people who have a chronic alcohol use disorder with people who do not.


COULD THIS STUDY BE RIGHT FOR YOU?

•    Adults ages 18-55 who have problem with alcohol use
•    Willing to not use alcohol for several weeks
•    Not taking prescription medication (birth control ok)
•    Willing and able to undergo 1 MRI, 1 CT and 1 PET scan


WHAT PARTICIPANTS CAN EXPECT

Study participation includes at least eight visits. An initial screening visit at WPIC takes about six hours to complete, and includes questionnaires, interviews, a physical exam, and a blood draw.

Participants are not permitted to use any alcohol or drugs within several weeks of the PET study and will be required to provide urine for drug testing.

People who qualify for the study will be required to come into UPMC Presbyterian Hospital/WPIC an additional six times to undergo MRI, PET, and CT scans, and other imaging-related procedures.

Participants will be seen for 12 weeks after the PET scans. During this 12-week period, a research therapist will meet with you in person three times a week to assess psychiatric symptoms and check urine drug screens. After completing the study, participants will be referred to a community addiction treatment program.


IRB:
  PRO16030103B - Linking nociceptive opioid peptide receptors (NOP) with relapse in alcohol use disorders

Age Range
AGE:   18 - 55

Duration DURATION:  4 Months
VISITS:  Multiple

Location LOCATION: 
Western Psychiatric Institute and Clinic (WPIC) & UPMC Presbyterian
Compensation COMPENSATION: 
Up to 1,747
Phone Number PHONE NUMBER:
1-866-438-8230
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Phone Number PHONE NUMBER:
1-866-438-8230

MEET THE RESEARCHER


Rajesh Narendran

Rajesh Narendran, MD, is an Associate Professor of Radiology at the University of Pittsburgh. Dr. Narendran specializes in using positron emission tomography (PET) radiotracers to understand the neurochemical abnormalities in stress-related and addictive disorders in humans. Aside from his work in research, Dr. Narendran is a fully licensed PA physician and a board-certified psychiatrist who treats drug/alcohol addicted and psychiatric patients at the UPMC WPIC re:solve crisis center.




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