Insomnia and Nighttime Urine Production

STUDY BASICS

Are you age 65 or older? Do you sleep poorly and wake up two or more times per night to urinate? If so, you may be able to participate in a research study to help better understand nighttime urine production and to find out if improving sleep affects nighttime urine production. Compensation provided.

STUDY PURPOSE

Waking up at night to pass urine—called nocturia—is a common problem, especially among older adults. In addition to disrupting sleep, nocturia increases the risk of falls, fractures, memory impairment, heart disease, and other problems. Recent research suggests that poor sleep quality plays a role in nocturia, but this relationship is not fully understood. The purpose of this study is to better understand nighttime urine production and to find out if improving sleep affects nighttime urine production in older adults. Researchers also hope that the information learned in this study might help development therapies for nocturia in the future.

COULD THIS STUDY BE RIGHT FOR YOU?

• Ages 65 and up
• Wake up 2 or more times per night to urinate
• Experience difficulty falling or staying asleep
• Feel that your sleep is not refreshing
• Do not have any of the following conditions: obstructive sleep apnea, restless legs syndrome, or sleep disorders such as sleepwalking, sleep terrors, sleep eating, or nightmare disorder

WHAT PARTICIPANTS CAN EXPECT

Participation involves an initial telephone screening with the study team to be sure you are eligible to participate. If eligible, participants will have 3 visits over 2 months. Participants will be randomly assigned (like the flip of a coin) to one of two sleep intervention groups. One group will receive behavioral sleep treatment and the other will receive sleep information with no behavioral treatment. Study procedures include completing questionnaires and a sleep diary, sleep assessments, blood draws, ultrasound, urinalysis, physical exam, and wearing an activity tracker.