MARS Research Study - Healthy Volunteers

STUDY BASICS

This is a study for looking for healthy individuals ages 40-70 who are not diagnosed with schizophrenia spectrum disorder (SSD). This research study is being conducted at the University of Pittsburgh/UPMC to help those with schizophrenia spectrum disorder (SSD) who are suffering side effects from the use of certain medications. Compensation is provided.

STUDY PURPOSE

This is a study of Anticholinergic Burden (ACB) reduction by lowering the dose of certain medications, (known as deprescription), in individuals with mid-to-late-life Schizophrenia Spectrum Disorders (SSD). ACB is the effect of taking multiple medications that block the actions in the nervous system. The study will examine the impact of ACB reduction and its effects on cognition, functional outcome, and quality of life. You are being asked to participate as a healthy control so that we can compare results to individuals with SSD.

COULD THIS STUDY BE RIGHT FOR YOU?

• are between the ages 40-70 years
• are not diagnosed with schizophrenia spectrum disorder (SSD)

WHAT PARTICIPANTS CAN EXPECT

At the beginning of the study, and at 6-months after you have joined the study:

• interviews
• questionnaires
• blood draws
• MR imaging scans