https://pittplusme.org/study/alcoholuse
Imaging CRF x NOP Interactions in Alcohol Use Disorder - Heavy Drinker
STUDY BASICS
Are you a heavy drinker or a problem drinker? Pitt research is seeking 18-55-year-old heavy alcohol drinkers. The purpose of this research study is to examine nociceptin which is a protein in the brain that regulates stress and promotes relapse. The study spans 4 months involving an interview, an MRI, 2 PET/CT scans, and an 8-week follow-up. Compensation is provided.
STUDY PURPOSE
The purpose of this research study is to combine the use of an experimental radioactive positron emission tomography imaging (PET) agent, [C-11]NOP-1A, and the medication hydrocortisone to examine nociceptin, a protein in the brain that regulates stress in alcohol use disorder.
COULD THIS STUDY BE RIGHT FOR YOU?
18-55-year-old heavy drinkers
WHAT PARTICIPANTS CAN EXPECT
Participation will span 4 months and includes an interview, an MRI, 2 PET/CT scans, and an 8-week follow-up period
IRB: STUDY25050039A
- Does a hyperactive nociceptin opioid peptide receptor system promote relapse in heavy drinking AUD subjects: a [C-11]NOP-1A and hydrocortisone PET study
MEET THE RESEARCHER
Rajesh Narendran
Dr. Rajesh Narendran, MD, is an Associate Professor of Radiology at the University of Pittsburgh. Dr. Narendran specializes in using positron emission tomography (PET) radiotracers to understand the neurochemical abnormalities in stress-related and addictive disorders in humans. Aside from his work in research, Dr. Narendran is a fully licensed PA physician and a board-certified psychiatrist who treats drug/alcohol addicted and psychiatric patients at the UPMC WPIC re:solve crisis center.