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Pitt+Me Weight Loss Research Study for Better Health – Colorectal Polyps


Did you have a colonoscopy with a polyp found and removed? Are you 18-84 years old? If so, you may be able to take part in a research study investigating how lifestyle changes affect weight, fitness level, quality of life, and certain biomarkers in people with a history of colorectal polyps. Compensation provided.


Colorectal polyps—small clumps of cells that form in the lining of the colon—are very common and affect about one in three Americans during their lifetime. People often have their colorectal polyps completely removed through surgery, but there is a chance that they will come back. Some studies have shown that excess body weight and low levels of physical activity increase the risk that colorectal polyps will return.

The purpose of this research study is to find out how diet and exercise programs affect weight, activity levels, quality of life, and biomarkers in people with a history of colorectal polyps. Biomarkers, or biological markers, are measurable substances in bodily fluids or tissues that can provide information about the body and may signal the presence of a condition or disease. Researchers hope their findings will lead to new ways to treat people with colorectal polyps and reduce the risk of cancer development in the future.


•    Ages 18-84
•    History of a colorectal polyp, under surveillance with no current sign of disease
•    BMI (body mass index) of at least 25 but less than 40


After an initial visit to find out if you are eligible for the study, participants will be randomly assigned (like the flip of a coin) to one of two weight control programs. Both programs are 6 months long and involve being placed on a diet, meetings in-person and/or over the phone, and study assessments taken before, during, and after the weight control program. One program includes an exercise component (walking) and the other does not. Assessments during the study include self-report forms, questionnaires, urine and blood samples, and physical measurements (body weight, blood pressure, fitness levels, etc.).

Your active participation in the study will last about 6 months, followed by a blood draw 12 months after joining the study, and yearly review of your medical records for up to 4 years.

  STUDY19070303B - Lifestyle Change for Better Health (LCBH) Study

Age Range
AGE:   18 - 84

Duration DURATION:  About 12 months
VISITS:  4 visits

Location LOCATION: 
University of Pittsburgh Physical Activity and Weight Management Research Center – Oakland
Compensation COMPENSATION: 
Up to $125
Phone Number PHONE NUMBER:
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John Jakicic

John M. Jakicic, PhD, FACSM, is Distinguished Professor and Chair in the Department of Health and Physical Activity and Director of the Healthy Lifestyle Institute and Director of the Physical Activity and Weight Management Research Center at the University of Pittsburgh. Dr. Jakicic’s research interests include the interaction between energy expenditure and energy intake, and the influence of these factors on body weight regulation and related health conditions.

Dana H. Bovbjerg

Dana H. Bovbjerg, PhD, is the Director of the Biobehavioral Oncology Program at UPMC Hillman Cancer Center and a Professor in the Departments of Psychiatry, Psychology, and Behavioral & Community Health Sciences at the University of Pittsburgh. Dr. Bovbjerg’s research focuses on biobehavioral factors in cancer, and includes studies of biobehavioral factors in cancer risk, response to treatment, and progression of disease. Dr. Bovbjerg received a doctorate in Neuroscience from the University of Rochester School of Medicine in Rochester, New York and an undergraduate degree in Psychology from the University of Iowa.

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