Are you an adult aged 18-75 who is living with HIV? Do you take antiretroviral medication to manage your HIV? You may be able to participate in a research study to learn more about the relationship between HIV, sleep quality, and inflammation. Participants will be asked to complete questionnaires, wear a special watch to track sleep, and provide blood and urine samples. Compensation is provided.
Antiretroviral medications used to manage HIV can cause changes to the immune system that may lead to increased levels of inflammation throughout the body. Poor sleep, which is commonly reported among people with HIV, is also associated with inflammation. Over time, inflammation can play a role in the development of heart and lung disease.
The purpose of this research study is to learn more about the relationship between HIV, sleep quality, and inflammation. Researchers hope their findings lead better ways to manage sleep problems in people living with HIV in the future.
COULD THIS STUDY BE RIGHT FOR YOU?
- Ages 18-75
- HIV positive
- Currently take antiretroviral medication
- Not pregnant
WHAT PARTICIPANTS CAN EXPECT
Participation includes two in-person visits. During the first visit, participants will be asked to complete questionnaires and will receive a watch-like device (similar to a Fitbit) that will be worn to track sleep patterns for two weeks. Each morning, participants will also answer a few questions about their sleep. At the end of two weeks, participants will return the watch, complete more questionnaires, and provide a urine and blood sample.
IRB:STUDY19040290A - Impact of Poor Sleep on Inflammation and the Adenosine Signaling Pathway in HIV Infection
MEET THE RESEARCHER
Sanjay R. Patel, MD, MS, is Professor of Medicine, Epidemiology, & Clinical and Translational Science at the University of Pittsburgh, Director of the Center for Sleep and Cardiovascular Outcomes Research, and Medical Director of the UPMC Comprehensive Sleep Disorders Program. Dr. Patel's research interests focus on understanding sleep disorders with particular emphasis on chronic partial sleep deprivation, obstructive sleep apnea, and the potential effects of these disorders on metabolism.