About Immune System/Infections
By deterring and defeating infections, the immune system defends the body from threats. Some diseases, such as HIV/AIDS, impair or disable the immune system, making the body more vulnerable to disease. Other conditions, such as rheumatoid arthritis and lupus, can cause the immune system to malfunction and begin to attack the body. Allergic reactions are excessive immune system responses as well, triggered by medications or foods or other foreign substances. By studying the immune system, researchers try to help the body’s defenses hold the line in the fight against disease and to prevent the body from turning those defenses on itself.
7T COVID Study –Participants with Severe Illness (NOT COVID-19)
Are you 45-80 years of age? Were you admitted to a UPMC hospital for a severe infection (such as pneumonia or skin infection) that was not COVID-19 in the past 6-15 months? You may be able to participate in a study that involves completing questionnaires, undergoing psychological testing, providing a blood sample, and undergoing a specialized MRI scan of the brain. Compensation is provided.
7T COVID Study
Are you 45-80 years of age? Were you admitted to a UPMC hospital for COVID-19 in the last 6-15 months? You may be able to participate in a study to identify the effects of COVID-19 infection on the brain. This study involves completing questionnaires, undergoing psychological testing, providing a blood sample, and undergoing a specialized MRI scan of the brain. Compensation is provided.
V-safe User Experiences
Have you received a COVID-19 vaccine? You may be able to participate in a study to help find out about user experiences with the v-safe app. V-safe was designed to provide personalized health check-ins after receipt of a COVID-19 vaccine. This study involves completing a 10-minute online survey about your background, health conditions, and familiarity with post-vaccine monitoring systems.
SASH Sleep Research Study – People Living with HIV
Are you an adult aged 18-75 who is living with HIV? Do you take antiretroviral medication to manage your HIV? You may be able to participate in a research study to learn more about the relationship between HIV, sleep quality, and inflammation. Participants will be asked to complete questionnaires, wear a special watch to track sleep, and provide blood and urine samples. Compensation is provided.
All of Us Pennsylvania Research Program
You may be able to change the future of medicine. The All of Us PA Research Program is enrolling adults 18 years of age or older. This may be your chance to improve how your children and your children’s children receive medical care.
HIV Research Registry
Are you interested in studies related to the treatment and prevention of HIV/AIDS and related conditions? HIV Research Registry members may be contacted by registry staff about studies for which they appear to qualify. Eligible participants are ages 18 and older.
MyPaTH Story Booth – COVID-19 Vaccine Stories
Have you thought about being vaccinated for COVID-19 or have you already received your COVID-19 vaccine? Are you interested in sharing your experience? You may be able to participate in a study to help learn more about COVID-19 vaccination experiences. This study involves 1 phone call lasting 45 minutes.
HIV Vaccine Study
Are you HIV-positive and doing well on your HIV medications? Are you aged 18-65? If so, you may be eligible to participate in a research study to find out if a vaccine made from a person’s own white blood cells can safely strengthen the body’s immune system. Participation lasts 80 weeks. Compensation and parking vouchers/bus tickets provided.
MyPaTH Story Booth 2.0
Interested in sharing your story about health, illness, or research? Patients and caregivers are needed to participate in a research study to help learn more about topics that are important to you and that may improve health and health care. Participation involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
NETI Research Study
Are you a person living with HIV? Have you been taking antiretroviral drugs that have been controlling your HIV for at least two years? You may be able to participate in a research study to find out if an investigational vaccine called Trimer 4571 is safe and well tolerated in people living with HIV and if it will help the body’s immune system respond to HIV. Compensation is provided.
MyPaTH Story Booth – COVID-19 Stories
Participants are invited to share how they are maintaining their health during the coronavirus pandemic, or to share what it is like being ill with COVID-19 and/or caring for a loved one who is ill with COVID-19. Participation in this research study involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
HIV Prevention Research Registry
Are you interested in learning about HIV prevention research studies taking place at the University of Pittsburgh and UPMC? If so, you can join the HIV Prevention Research Registry. HIV prevention registry members may be contacted by registry staff members about studies for which they appear to qualify. Eligible participants are ages 18 and older.
Have you recently been diagnosed with COVID-19 and have a child under the age of 18 living in your household? You and your child may be able to participate in a study that is looking at how COVID-19 infections spread in people living in the same house. You will be asked to swab your child's nose with a provided swab up to 2 times and complete a symptom diary. Compensation is provided.
Loss of Smell after COVID Study – Ages 18-21
Have you lost your sense of smell? Could it be from COVID-19 infection? You may be able to participate in a study that is looking at the effects of smell retraining therapy for those who have lost their sense of smell due to COVID-19 infection. This study involves up to 4 visits over one year and being randomly assigned to one of two treatments for loss of smell.
Long COVID-19 Study
Patients aged 18-80 previously hospitalized with COVID-19 due to breathing issues are invited to join a clinical trial. The study is exploring the safety and effectiveness of a potential investigational treatment to prevent long-term lung damage from the virus. Study participation may last up to 110 days. Reimbursement and UPMC parking voucher offered for each completed study visit.
Reproductive Outcomes of Women with Rheumatic Diseases
Are you an 18-44 year old woman who is diagnosed with an autoimmune disease (also called rheumatic disease)? Do you take medication for your disease? You may be able to participate in a research study to learn more about reproductive decisions in women who have autoimmune diseases. This study involves completing a questionnaire once every three months. Compensation is provided.
COVER STUDY: The COVID-19 Vaccine in Rheumatic Disease Patients
Do you have one of the following autoimmune diseases: Rheumatoid arthritis, scleroderma, myositis, or Sjogren’s syndrome? Are you planning on receiving a COVID-19 vaccine? You may be able to participate in a study to determine the effect of the vaccine on your autoimmune disease. This study involves 9 visits over 4 months. Four of the visits will take place in-person and 5 visits by phone.
Prevention of Recurrent Clostridium Difficile Infection in Inflammatory Bowel Disease
Do you have inflammatory bowel disease (IBD) such as ulcerative colitis or Crohn’s disease? Are you currently being treated with antibiotics for Clostridium difficile (C. diff) infection? You may be able to participate in a research study to help find out if a drug used for the prevention of C. diff works to break the cycle of the infection in people with IBD. Compensation provided.
COVID-19 Vaccine Multiple Sclerosis Survey Study - Participants with and without MS
Researchers at the University of Pittsburgh are seeking adults with and without a diagnosis of multiple sclerosis or other neuroinflammatory disease for a survey study to help understand your feelings about the COVID-19 vaccine. Participants in this research study may or may not have already received the COVID-19 vaccine. Participation involves completing multiple surveys over one year