Are you age 75 or older? You may be able to participate in a research study to help find out if taking a statin drug may help older adults live well for longer by preventing dementia, disability, or heart disease. Participation in the study may last up to five years. Currently, all study visits will take place by videoconference and phone. Compensation is provided.
Statins are drugs that are used to lower the level of bad cholesterol in the body. For people diagnosed with heart disease or at high risk for developing heart disease, statin drugs can help prevent heart attacks and strokes. Some research suggests that statins may also have benefits for older adults who do not have heart disease, but these effects are not fully understood. The purpose of this research study is to find out if a drug called atorvastatin, a statin with the brand name Lipitor®, can help older adults live well for longer by preventing dementia, disability, or heart disease.
COULD THIS STUDY BE RIGHT FOR YOU?
- Ages 75 and up
- Do not have heart disease (heart attack or stroke), dementia, or a significant disability that limits your basic everyday activities
WHAT PARTICIPANTS CAN EXPECT
Participation in the study may last up to five years. Currently, all study visits will take place by online videoconference by phone. Participants will be randomly assigned (like the flip of a coin) to receive either atorvastatin (study drug) or a matching placebo (a tablet that looks like atorvastatin but does not contain any medicine). Participation includes completing brief memory and physical tests. In the future (post-COVID-19), participation may also include in-person visits and blood draws.
IRB:Pro00103930 - PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldER adults (PREVENTABLE)
MEET THE RESEARCHERS
Daniel E. Forman, MD, is Professor of Medicine at the University of Pittsburgh School of Medicine. The founder of the American College of Cardiology’s geriatric cardiology section, Dr. Forman researches new and novel treatments for seniors with heart problems to help them live full lives.
Aryan Narayan Aiyer
Aryan Aiyer, MD, is Assistant Professor of Medicine at the University of Pittsburgh School of Medicine and Medical Director of the UPMC Heart and Vascular Institute Lipid Clinic. Dr. Aiyer's research focuses on cardiac risk factors and preventive cardiology.