The Effects of Fasting on Lipid Metabolic Profile and Bone Metabolism

STUDY BASICS

Are you 25 to 45 years old? Do you have a parent, sibling, or child with type 2 diabetes or did you have gestational diabetes (diabetes that develops in pregnancy)? If so, you may be eligible for a research study assessing the effects of fasting for one day a week for 3 months. Compensation provided.

STUDY PURPOSE

The purpose of this research study is to better understand the effects of fasting on the metabolic profile and bone metabolism in healthy normal-weight individuals at high risk for developing diabetes mellitus. This would help us understand the potential benefits and risks of caloric restriction.

COULD THIS STUDY BE RIGHT FOR YOU?

• Healthy adult, ages 25-45 with a BMI (body mass index) between 21 and 30
• Taking no regular medications and no chronic medical conditions
• Not using hormonal contraception (the Pill, hormonal IUD or hormonal implant)
• Has a parent, sibling, or child with type 2 diabetes or a personal history of gestational diabetes (diabetes that develops in pregnancy)

WHAT PARTICIPANTS CAN EXPECT

Participation includes 13 study visits over an approximately 9-month period. After an initial screening visit (1 hour), the study requires fasting for 1 day per week for 12 weeks. At the beginning and end of this 12 weeks, you will come in for a long day of testing (about 8 hours) – so there are two long days about 3 months apart. During the fasting period, we will see you in person for about 20 minutes every 10 days to change your glucose monitor and measure your weight. At some of the visits, we will draw blood. We will also ask you to keep track of your food before some of your visits, as well as wear a Fitbit throughout the study to track your physical activity. The final visit occurs 3 months after you finish the fasting period; this visit takes about 1 hour.