PREPARE 2 - Healthy Volunteers
STUDY BASICS
Are you a healthy adult? You may be eligible for a research study investigating how ketamine (a non-opioid drug that is commonly used for surgical procedures) may help reduce pain and symptoms of depression. Compensation is provided.
STUDY PURPOSE
The PREPARE 2 study aims to better understand how patients who have just had a cesarean delivery metabolize ketamine (a non-opioid drug that is commonly used for surgical procedures). PREPARE2 is enrolling healthy and non-pregnant people as a comparison group. This study is investigating how this medication may help reduce pain and symptoms of depression.
COULD THIS STUDY BE RIGHT FOR YOU?
- At least 18 years of age
- Not currently pregnant or breastfeeding
- Not currently undergoing hormonal therapy
WHAT PARTICIPANTS CAN EXPECT
- Complete a series of questionnaires prior to your research unit inpatient ketamine infusion.
- Receive an infusion of ketamine lasting 12 hours and undergo 12 additional hours of monitoring immediately after.
- Complete weekly questionnaires about your mood and pain throughout the first 3 months post-infusion.
IRB: STUDY22100019
- Ketamine Pharmacokinetics and Pharmacodynamics for Pain and Postpartum Depression after Cesarean DeliveryMEET THE RESEARCHER

Grace Lim
Grace Lim, MD, MS, is a physician scientist and board-certified obstetric anesthesiologist who has dedicated her clinical, educational, and research career to improving health and outcomes for mothers and babies. Dr. Lim’s research focuses on acute clinical care and interventions in periods of stress and trauma, such as childbirth or surgery, so that long-term recovery and maternal and neonatal health are optimized.