https://pittplusme.org/study/5daycoldsleep
Five-Day Cold Sleep
STUDY BASICS
Are you 18-55 years old and healthy? You may be eligible for a research study to test medications for astronauts that increase the total hours of sleep each day and reduce metabolism. This may conserve oxygen and food and reduce discomfort while in a spaceship. The study involves four separate visits over 3 weeks to a laboratory in Oakland. Compensation is provided.
STUDY PURPOSE
Purpose of the study is to identify a method that can lower activity and metabolism in astronauts during long spaceflights in order to conserve oxygen, food, and reduce the psychological stress from being confined in a spaceship for multiple weeks.
COULD THIS STUDY BE RIGHT FOR YOU?
- 18-55 years of age
- Healthy
WHAT PARTICIPANTS CAN EXPECT
- Four separate visits over 3 weeks to a laboratory in Oakland
- One visit requires 6 days staying, sleeping and eating in the laboratory
- Requires blood draws
- May take sedating medication or take saline as a control subject
- Requires 2 DEXA scans (x-rays) before and after the 6-day visit
- Requires wearing monitors and keeping a diary at home for 2 weeks
IRB: STUDY24020060
- Enhanced Sleep for Long-Duration Spaceflight
MEET THE RESEARCHER
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Clifton Callaway
Dr. Callaway is Distinguished Professor, Vice-Chair, and Ronald D. Stewart Endowed Chair in Emergency Medicine Research at the University of Pittsburgh School of Medicine. He completed his PhD in Neuroscience (1992) and MD (1993) at the University of California, San Diego, followed by residency in Emergency Medicine at the University of Pittsburgh (1996). He and partners lead a multidisciplinary clinical service to advance the care of patients after cardiac arrest, with particular focus on promoting recovery from brain injury. Past research includes leadership for multiple clinical trials in emergency and acute care, implementation of therapies used by emergency medical services, and translational research on neurological effects of temperature manipulation. Currently, Dr. Callaway helps lead the clinical coordinating center for SIREN, an National Institutes of Health emergency research trial network of over 75 medical centers that conducts clinical trials in acute care. He has contributed to national and international guidelines for advanced life support since 2008.