Multi-Modal Study - Non-bipolar

STUDY BASICS

Do you have periods (at least 3-5 days) where you act without thinking, become easily irritated, feel frustrated when things don’t go your way, or feel excited when you may win a contest? Or, do you have any first-degree relatives that may have a history of Bipolar Disorder? You may be eligible for a research study to observe the effects of medication on brain activity in adults.

STUDY PURPOSE

This research study will examine how medication affects the brain in young adults with Bipolar Disorder and healthy controls without Bipolar Disorder.

COULD THIS STUDY BE RIGHT FOR YOU?

• Ages 18-35 years old
• Have periods in your life, for at least 3-5 days, where you persistently act without thinking, become easily irritated, feel frustrated when things don’t go your way, or feel excited when you may win a contest. Or, have any first-degree relatives that you think may have a history of Bipolar Disorder.  (First degree relatives are your parents, your full siblings and your children.)

WHAT PARTICIPANTS CAN EXPECT

Participants will complete 5-6 study visits. The study procedures include:

• questionnaires about topics like your health history and feelings
• routine health screening like physical exams, blood draws, and EKGs
• urine and saliva tests for drug and alcohol use
• urine pregnancy tests if you have childbearing potential
• Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET) scans of your brain
• computer tasks that may require you to push buttons
• one time use of an oral medication commonly prescribed for ADHD (dextroamphetamine/d-amphetamine)