Are you less than 21 weeks pregnant with your first child? If so, you may be able to participate in a research study to identify pregnant women with sleep apnea and to find out if using a CPAP machine can lower the risk of developing preeclampsia and gestational diabetes in pregnant women with sleep apnea. Participants must be overweight and/or snore at least 3 times a week. Compensation provided.
STUDY PURPOSESleep apnea—a disorder in which the airway is blocked during sleep, causing difficulty breathing and frequent snoring—is a common problem during pregnancy. Studies have shown that women with sleep apnea are at an increased risk for the development of health problems such as high blood pressure and diabetes, both of which can lead to serious complications during pregnancy. The most common treatment for sleep apnea is a continuous positive airway pressure (CPAP) machine that helps to keep the airway open while sleeping, but research into the use of CPAP machines during pregnancy is limited. The purpose of this research study is to identify pregnant women with sleep apnea and to find out if using a CPAP machine can lower the risk of developing preeclampsia (high blood pressure during pregnancy) and gestational diabetes (diabetes during pregnancy) in pregnant women with sleep apnea.
COULD THIS STUDY BE RIGHT FOR YOU?
- Females aged 18-55
- Less than 21 weeks pregnant with first baby
- Pregnant with one baby
- Are overweight, with a body mass index (BMI) over 30 and/or snore more than 3-4 times per week
- Receiving pregnancy care at UPMC Magee-Womens Hospital or UPMC Mercy
WHAT PARTICIPANTS CAN EXPECTThis study involves two parts. During the first part, participants will go home with a portable sleep monitor to find out if they have sleep apnea. Women who have sleep apnea and are interested and eligible may continue to the second part of the study. During the second part of the study, participants will be randomly assigned (like the flip of a coin) to either the CPAP study treatment group or the advice on getting good sleep group. Participants will have at least two visits and will be regularly contacted throughout the study. Study procedures will include blood draws, body measurements, and answering questionnaires.
IRB:STUDY19050120 - A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy (SLEEP)
MEET THE RESEARCHER
Hyagriv Simhan, MD, MSCR, is professor at the University of Pittsburgh School of Medicine, and chief of the division of maternal-fetal medicine and medical director of obstetrical services at Magee-Womens Hospital of UPMC. His main area of research has been on preterm birth. Because of his efforts to improve patient safety and quality of care, Dr. Simhan has been awarded the Fine Award from the Pittsburgh Regional Health Initiative, and the Achievement Award for Health Care Quality Improvement/Patient Safety from the Hospital Association of Pennsylvania.