https://pittplusme.org/study/2308
IMSA 2 Healthy Volunteers
STUDY BASICS
You may be able to participate in a research study that is being done to learn more about the way asthma impacts your airway, and how these changes compare to changes in your clinical condition and breathing tests.
STUDY PURPOSE
Severe asthma, which affects approximately 5%-10% of asthmatics, is poorly understood and difficult to treat. Researchers think that people with severe asthma may have differences in their lungs and blood, when compared to people with milder forms of asthma or no asthma. The purpose of this research study is to look at these differences and find out how they are related to your symptoms and asthma flares over one year.
COULD THIS STUDY BE RIGHT FOR YOU?
We will enroll approximately 100 adults between 18 and 70 years of age. We are looking for individualswho do not have asthma to serve as healthy controls for this arm of the study. Participation will be for approximately 1 year (3-6 office visits and 6 telephone calls).
IRB: STUDY22020208B
- Immune Airway-Epithelial Interactions in Steroid-Refractory Severe Asthma 2
MEET THE RESEARCHER
Sally Wenzel
Dr. Sally Wenzel completed her MD degree at the University of Florida and spent 19 years at National Jewish and the University of Colorado before moving to the University of Pittsburgh. She received numerous awards from the American Thoracic Society and the European Respiratory Society. She is currently Director of the University of Pittsburgh Asthma and Environmental Lung Health Institute at UPMC, and Chair for the Department of Environmental and Occupational Health, at the School of Public Health, University of Pittsburgh. Dr. Wenzel has a passion for improving the understanding of the prevention and treatment of asthma, in particular severe asthma, where both genetic and environmental factors are likely to be playing a role. She has performed research bronchoscopies on hundreds of asthma patients, studies critical to identifying the heterogeneity of asthma, including the influence of T2, T1 and innate immunity. Her current bench-lab interests include the role of epithelial cells in the modulation of redox balance, inflammation, mucus production and clearance in the airways. She now chairs the Department of Environmental and Occupational Health at the University of Pittsburgh, where she is leading efforts to address the effects of the environment and its various pollutants to impact oxidative stress in airway epithelial cells of asthmatic patients. She has authored more than 350 publications and is the recipient of numerous awards including the European Respiratory Society (ERS) Presidential Award in 2017, the American Thoracic Society (ATS) Foundation Breathing for Life 2016 Award, and the ATS Amberson Lecture in 2021 for her career work in all aspects of asthma. As Chair of Environmental and Occupational Health, she is dedicated to improving the air and water quality of our region and its disproportionate impact on the health of people of color.