About Substance Use
Substance use occurs when a person uses mind-altering substances such as alcohol or drugs. While not everyone who uses these substances develops a problem, alcohol and drug misuse leads to harmful consequences for many individuals and families. Because alcohol and drugs change the brain, controlling intake can be challenging, quitting can be difficult, and relapses are common. Researchers studying substance use and misuse want to learn more about the complex interactions between biology (e.g., genetics, mental disorders) and environment (e.g., peer pressure, history of abuse, stress) in people who use alcohol and drugs. Over time, these findings may lead to new ways to predict behaviors and treat those who misuse substances.
Social Nicotine Smokers (Cigarettes or Vapes) - CRF-NOP Brain Imaging Study
Social nicotine smokers (cigarette or vape) between 30 and 50 years of age are needed for a brain imaging research study. Participation involves questionnaires, interviews, brain scanning (1 MRI and 2 PET scans), and the administration of intravenous hydrocortisone. Compensation provided.
Alcoholic Hepatitis Network Observational Study - Heavy Drinkers
Do you actively consume alcohol - do you consume at least 20 drinks per week (women) and at least 30 drinks per week (men) and have no known history of liver diseases? Participants will undergo a physical exam, blood draws, provide urine and stool samples, and complete questionnaires.
Neuro Study for Pregnant Women in an Opioid Replacement Therapy Program
Are you currently pregnant and taking Subutex (Buprenorphine), Suboxone, or Methadone? You may be able to participate in a study to evaluate the effects of these medications on the fetal and newborn baby’s brain. There are four parts to this study, and you may choose to participate in one or more parts. Compensation is provided for all parts of the study.
Are you between the ages of 21-30 and drink alcohol weekly? If so, you may be able to participate in a research study to help learn more about the effects of alcohol on thoughts, decisions, and behaviors. Eligible participants need to identify as Latine/Hispanic, African American/Black or European American/White. Compensation is provided.
The Alcohol Survey Knowledge (ASK) Study
Are you between the ages of 21 and 60 and would you say that you have been a heavy drinker (i.e. 4 or 5 drinks twice/month for a three month period) within the past 2 years? You may be able to participate in a research study that will help to understand how people describe their experience with impaired control over alcohol use.
Do you have COPD? You may be able to participate in a study to evaluate the ability of a study drug, called benralizumab, to improve lung function and reduce the rate of moderate and severe COPD flare-ups. Eligible participants are 40-85 years old and are current or ex-smokers. Participation will last about 56 weeks and will involve several visits. Reimbursement for visits and parking/bus voucher.
Cocaine Users – CRF-NOP Brain Imaging Study
Cocaine users between 18-50 years old are needed for a brain imaging research study to help learn more about the role of a protein in cocaine use. Participation involves questionnaires, interviews, brain scanning (1 MRI and 2 PET scans), and the administration of intravenous hydrocortisone. Compensation provided.
Cannabis Reactions, Effects, Acute Thoughts, and Experiences (CREATE) Study
Do you use cannabis? If you are between the ages of 18 to 25 and use cannabis at least weekly, you may be eligible to participate in a research study. The CREATE Study examines cannabis use, mood, experiences, and behaviors in the lab and throughout your day. We offer evening hours and weekends for study visits to fit your schedule.
MyPaTH Story Booth 2.0
Interested in sharing your story about health, illness, or research? Patients and caregivers are needed to participate in a research study to help learn more about topics that are important to you and that may improve health and health care. Participation involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
MyPaTH Story Booth – COVID-19 Stories
Participants are invited to share how they are maintaining their health during the coronavirus pandemic, or to share what it is like being ill with COVID-19 and/or caring for a loved one who is ill with COVID-19. Participation in this research study involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
Benzodiazepine Discontinuation Study
Are you currently receiving opioid maintenance treatment (methadone or buprenorphine)? And do you regularly take benzodiazepines (such as Valium, Klonopin, or Xanax) and are interested in discontinuing benzodiazepine use? You may be able to participate in a research study that will help you to slowly stop taking benzodiazepines by teaching you skills to help with withdrawal.
Craving and Smoking Behavior Study
Are you 26-55 years old and interested in quitting smoking? You may eligible for a study to test new methods aimed at helping individuals quit smoking. This is not a treatment study. This study includes 10 in-person visits. Study procedures involve completing questionnaires and undergoing an EEG (measures brain activity) and tDSC (non-invasive brain stimulation). Compensation is provided.
MAPS Research Study – Teens Age 18
Are you an 18 year old who has been diagnosed with anxiety, depression, or substance use disorder? If so, you may be eligible to participate in a research study to help find out if smartphone technology can be used to better understand suicidal thoughts and behaviors in high-risk teens. Compensation provided.
Mood, Alcohol Response, and Sleep
Are you aged 21-30 and do you drink alcohol on a weekly basis? If so, you may be eligible to participate in a research study to help better understand how sleep relates to your mood, thoughts, and behaviors, including drinking alcohol. Involves 3 lab visits, 2 separate overnight visits, answering questionnaires on a smartphone, and wearing an activity tracker wristband. Compensation provided.
All of Us Pennsylvania Research Program
You may be able to change the future of medicine. The All of Us PA Research Program is enrolling adults 18 years of age or older. This may be your chance to improve how your children and your children’s children receive medical care.
Using Smartphone Assessments for Alcohol Use
Are you 18-25 years old and own a smartphone? You may be able to participate in a research study to understand drinking behavior in young adults. Study involves 1 in-person visit, completion of twice daily online questionnaires for 120 days, use of a Breathalyzer to record your blood alcohol content each evening and after drinking, and 3 follow-up phone/internet sessions. Compensation provided.
Brain Imaging Research Study – Cocaine Users
Do you currently use cocaine or have you recently used cocaine? Are you aged 18–55? You may be able to participate in a research study to help learn more about two proteins in the brain that may play a role in substance use disorders. Compensation is provided.
Brain Imaging Research Study - Social Smokers and Vapers
Are you aged 18–55 and smoke or vape nicotine-containing products at least twice per month? You may be able to participate in a research study to learn more about a protein in the brain that may play a role in substance use disorders. Compensation is provided.
Biobehavioral Characteristics of Smokers
Are you 18-49 years old, a current smoker, and able to speak fluent English? You may be able to take part in a research study to learn more about the characteristics of current smokers. This study involves 1 screening visit and 2 study visits, with one of the visits involving an MRI brain scan. Participants must be willing to not smoke for 8 hours before the 2 study visits. Compensation provided.
HOPE Buprenorphine Stigma Study
Do you have an active end-stage kidney disease diagnosis and have undergone in-center dialysis treatment within the past 3 months? You may be able to participate in a study to better understand chronic pain and opioid stigma in individuals with end-stage kidney disease on dialysis. Eligible participants will complete an audio-recorded interview that will last one hour. Compensation is provided.
Q-PRONTO Research Study – Pregnant and on MAT
Are you in your third trimester of pregnancy (at least 28 weeks pregnant)? Are you currently on medication-assisted treatment (MAT) for opioid use disorder? You may be able to participate in a study to evaluate third trimester and postpartum pain sensitivity in patients with and without history of opioid use. This study involves 2 visits lasting about 1 hour total. Compensation is provided.
CTN-0080 MOMs Study
Are you a pregnant woman who uses opioids or is currently prescribed Suboxone, Subutex, or Zubsolv? You may be able to participate in a research study to compare the safety and effectiveness of two different forms of buprenorphine for pregnant women and their unborn children. The study begins while you are pregnant and continues until 12 months after you have given birth. Compensation is provided.
Ketamine in Opioid-Tolerant Patients Undergoing Spine Surgery
Do you take prescription opioid pain relievers for back pain and are you scheduled to have lumbar, thoracic, or cervical spine surgery? Are you 18-70? You may be able to take part in a research study to better understand how ketamine affects pain and opioid use after surgery. Eligible participants are scheduled for surgery with Dr. Okonkwo or Dr. Hamilton. Compensation will be provided.