About Substance Use
Substance use occurs when a person uses mind-altering substances such as alcohol or drugs. While not everyone who uses these substances develops a problem, alcohol and drug misuse leads to harmful consequences for many individuals and families. Because alcohol and drugs change the brain, controlling intake can be challenging, quitting can be difficult, and relapses are common. Researchers studying substance use and misuse want to learn more about the complex interactions between biology (e.g., genetics, mental disorders) and environment (e.g., peer pressure, history of abuse, stress) in people who use alcohol and drugs. Over time, these findings may lead to new ways to predict behaviors and treat those who misuse substances.
Alcohol Survey Knowledge (ASK) Study
Are you 21-45 years old and drink alcohol weekly? You may be eligible for a research study to learn more about how people describe their experiences related to alcohol use. Compensation is provided.
ENDALI Research Study – Individuals who Vape
Are you 18-80 years old? Have you vaped weekly for at least the past 3 months? You may be able to participate in a study to learn about the potential for lung disease from vaping and vaping products. This study involves 1 in-person visit lasting about 4 hours. Study procedures involved providing sputum, saliva, blood, and stool samples. Compensation is provided.
All of Us Pennsylvania Research Program
You may be able to change the future of medicine. The All of Us PA Research Program is enrolling adults 18 years of age or older. This may be your chance to improve how your children and your children’s children receive medical care.
MyPaTH Story Booth – COVID-19 Stories
Participants are invited to share how they are maintaining their health during the coronavirus pandemic, or to share what it is like being ill with COVID-19 and/or caring for a loved one who is ill with COVID-19. Participation in this research study involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
MyPaTH Story Booth 2.0
Interested in sharing your story about health, illness, or research? Patients and caregivers are needed to participate in a research study to help learn more about topics that are important to you and that may improve health and health care. Participation involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
Optimizing Retention, Duration and Discontinuation Strategies for Opioid Use Disorder Pharmacotherapy
Are you newly seeking treatment for heroin or other opioids? Are you 18 or older? You may be eligible for a research study to test treatment approaches, including medications, to help patients with opioid use disorder stay in treatment.
Cocaine Users – CRF-NOP Brain Imaging Study
Cocaine users between 18-50 years old are needed for a brain imaging research study to help learn more about the role of a protein in cocaine use. Participation involves questionnaires, interviews, brain scanning (1 MRI and 2 PET scans), and the administration of intravenous hydrocortisone. Compensation provided.
Brain Imaging Research Study – Cocaine Users
Do you currently use cocaine or have you recently used cocaine? Are you aged 18–55? You may be able to participate in a research study to help learn more about two proteins in the brain that may play a role in substance use disorders. Compensation is provided.
Brain Imaging Research Study - Social Smokers and Vapers
Are you aged 18–55 and smoke or vape nicotine-containing products at least twice per month? You may be able to participate in a research study to learn more about a protein in the brain that may play a role in substance use disorders. Compensation is provided.
DBS for Addiction
Are you between ages 21-75 and diagnosed with severe alcohol use disorder? If so, you may be eligible to participate in a research study determining if deep brain stimulation (DBS) can improve symptoms of alcohol use disorder. Compensation is provided.
Neuro Study for Pregnant Women in an Opioid Replacement Therapy Program
Are you currently pregnant and taking Subutex (Buprenorphine), Suboxone, or Methadone? You may be able to participate in a study to evaluate the effects of these medications on the fetal and newborn baby’s brain. There are four parts to this study, and you may choose to participate in one or more parts. Compensation is provided for all parts of the study.
Are you between the ages of 21-30 and drink alcohol weekly? If so, you may be able to participate in a research study to help learn more about the effects of alcohol on thoughts, decisions, and behaviors. Eligible participants need to identify as African American/Black. Compensation is provided.
Do you have COPD? You may be able to participate in a study to evaluate the ability of a study drug, called benralizumab, to improve lung function and reduce the rate of moderate and severe COPD flare-ups. Eligible participants are 40-85 years old and are current or ex-smokers. Participation will last about 56 weeks and will involve several visits. Reimbursement for visits and parking/bus voucher.
Cannabis Reactions, Effects, Acute Thoughts, and Experiences (CREATE) Study
Do you use cannabis? If you are between the ages of 18 to 25 and use cannabis at least weekly, you may be eligible to participate in a research study. The CREATE Study examines cannabis use, mood, experiences, and behaviors in the lab and throughout your day. We offer evening hours and weekends for study visits to fit your schedule.
Craving and Smoking Behavior Study
Are you 26-55 years old and interested in quitting smoking? You may eligible for a study to test new methods aimed at helping individuals quit smoking. This is not a treatment study. This study includes 10 in-person visits. Study procedures involve completing questionnaires and undergoing an EEG (measures brain activity) and tDSC (non-invasive brain stimulation). Compensation is provided.
Biobehavioral Characteristics of Smokers
Are you 18-49 years old, a current smoker, and able to speak fluent English? You may be able to take part in a research study to learn more about the characteristics of current smokers. This study involves 1 screening visit and 2 study visits, with one of the visits involving an MRI brain scan. Participants must be willing to not smoke for 8 hours before the 2 study visits. Compensation provided.
Q-PRONTO Research Study – Pregnant and on MAT
Are you in your third trimester of pregnancy (at least 28 weeks pregnant)? Are you currently on medication-assisted treatment (MAT) for opioid use disorder? You may be able to participate in a study to evaluate third trimester and postpartum pain sensitivity in patients with and without history of opioid use. This study involves 2 visits lasting about 1 hour total. Compensation is provided.
CTN-0080 MOMs Study
Are you a pregnant woman who uses opioids or is currently prescribed Suboxone, Subutex, or Zubsolv? You may be able to participate in a research study to compare the safety and effectiveness of two different forms of buprenorphine for pregnant women and their unborn children. The study begins while you are pregnant and continues until 12 months after you have given birth. Compensation is provided.