About Bones, Joints, and Muscles
Bones, joints, and muscles act as scaffolding for the body. Bones are a living part of the body that anchor the softer organs while also shielding them from harm. Conditions like scoliosis can twist the spinal column while other conditions, like osteoporosis, can weaken bones and make breaks more likely. Joints are the connections between bones, held together by ligaments. Muscles are attached to bones by tendons which allows them to move joints. If muscles, ligaments, and tendons are put under too much tension or irritation, they can become torn, strained, or inflamed. Research that helps us learn more about bones, joints, and muscles could provide many with improved support, flexibility and movement.
EN20-01 Knee Osteoarthritis Study
Are you ages 45-80? Have you had knee pain from osteoarthritis for at least the past 6 months? You may be able to participate in a study to find out if an investigational medicine called CNTX can treat knee pain caused by osteoarthritis (OA). Participation involves 10 visits over 6 months. Compensation is provided.
Above the Knee Amputee Research Study
Are you 18-80 years old? Do you have an above the knee amputation and are walking in a conventional socket prosthesis? You may be able to participate in a study to find out how socket design changes affect comfort and mobility for amputees. Participation involves undergoing a CT scan, high-speed X-ray imaging, and ultrasound. Compensation is provided.
STEP-HI: Hip Fracture Recovery Research Study
Are you a woman age 65 or older who had surgery to repair a hip fracture within the past five months? You may be eligible to participate in a research study to help find out if an exercise program, with or without hormone replacement therapy, improves physical functioning after a hip fracture. Transportation is provided.
Bone Adaptations to Physical Training
The primary purpose is to determine the bone density, structure and strength adaptations that result from various exercise programs which differ based on the frequency and intensity of bone loading. Subjects will complete 24 weeks of resistance training or maintain their current activity level without beginning any formal exercise training program and participate in laboratory visits.
LB3P: Low Back Pain Research Study
Have you had low back pain for more than 3 months? If so, you may be able to participate in a research study to help better understand the factors that contribute to low back pain. This study involves one in-person visit and eight online sessions over 1 year. Compensation is provided.
MyPaTH Story Booth 2.0
Interested in sharing your story about health, illness, or research? Patients and caregivers are needed to participate in a research study to help learn more about topics that are important to you and that may improve health and health care. Participation involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
MyPaTH Story Booth – COVID-19 Stories
Participants are invited to share how they are maintaining their health during the coronavirus pandemic, or to share what it is like being ill with COVID-19 and/or caring for a loved one who is ill with COVID-19. Participation in this research study involves one 45-minute session that takes place over the phone. Eligible participants must be able to read and understand English.
Spinal Cord Stimulation for the treatment of motor deficits in people with Spinal Muscular Atrophy
Are you affected by Spinal Muscular Atrophy? You may be able to participate in a research study using spinal cord stimulation (SCS), an approved clinical therapy for pain syndromes that do not respond to drugs. Unexpectedly, SCS has shown the ability to promote the recovery of leg motor function in people with complete motor paralysis in consequence of spinal cord injury years after injury.
All of Us Pennsylvania Research Program
You may be able to change the future of medicine. The All of Us PA Research Program is enrolling adults 18 years of age or older. This may be your chance to improve how your children and your children’s children receive medical care.
Pepper Center Research Registry for Older Adults
Are you at least 60 years old? If so, you may be able to take part in the Pepper Center Research Registry to help researchers learn more about aging, mobility, and balance.
Caregiver Assisted Transfer Technique Instrument (CATT) Evaluation Study – Care Recipient
Have you had a physical disability diagnosis for at least the past 2 years? Do you use a wheeled mobility device at least 30 hours/week, and require assistance with transfers? You and your caregiver may be able to participate in a study to evaluate CATT by using it to find out how individuals with physical disabilities and their caregivers perform assisted transfers. Compensation is provided.
Chronic Low Back Pain with Mood Symptoms Study
Have you had chronic low back pain for at least six months and also have depression or anxiety symptoms? Are you aged 18-75? You may be able to participate in a research study to compare antidepressant medication and physical therapy for people with chronic low back who also have anxiety and depression symptoms. Compensation is provided.
Knee Osteoarthritis Pain Study
Are you 45-80 years old and have chronic knee pain associated with knee osteoarthritis? You may be able to participate in a research study to help find out how the body responds to pain. This study involves one in-person visit that lasts about four hours. Compensation is provided
Are you currently experiencing low back pain? Did this episode of back pain start in the last three months? You may be eligible to participate in a research study comparing different therapies to treat low back pain and prevent it from reoccurring in the future. Participants will be compensated.
Opportunities to Improve Recovery after Injury
Have you been involved in a physical injury that resulted in seeking Emergency Department treatment within the past 30-days? You may be able to participate in a research study to help us learn how to improve the recovery process. Participation involves downloading and using a mobile phone for 1-week, then sharing your feedback and recovery experiences in a 60-minute online interview.
OPTIMUM Research Study
Are you bothered by chronic low back pain? You may be able to participate in a research study to find out if group mindfulness meditation sessions, coordinated with your primary care provider, can help reduce chronic low back pain. This study involves surveys, an interview, and monthly virtual visits. Some participants will also attend weekly online group sessions. Compensation is provided.
Muscle Loss Research Study
Have you suffered from muscle and tendon tissue loss to your arm and/or leg due to a traumatic injury in the past 18 months? You may be able to participate in a study to examine the ability of a surgical graft to restore your muscle cells in the area of your injury. Eligible participants are 18-70 years old and are at least 3 months from initial injury. Reimbursement is provided.
Do you have a leg amputation above the ankle and below the knee? Did your amputation occur more than 6 months ago? You may be able to participate in a research study to help develop a neuroprosthetic device that stimulates nerves with the goal of producing sensations that feel like they come from the amputated limb. Eligible participants are 22-70 years old. Compensation is provided.
Hormonal Skin Patch for Women with Anorexia Nervosa
Are you a 19-45 year old woman diagnosed with anorexia nervosa? You may be able to participate in a research study to help find out if a hormonal skin patch can improve bone density in women with anorexia nervosa. Participation involves imaging studies, blood tests, and nutritional analyses. Compensation is provided.
Have you been diagnosed with osteopenia (bone loss) by your doctor? You may be eligible to participate in a research study to find out if a natural treatment option that includes weight-bearing exercises (called osteogenic loading) and melatonin supplements can improve bone health and overall quality of life in people with osteopenia and reduce the risk of developing osteoporosis.
Ketamine in Opioid-Tolerant Patients Undergoing Spine Surgery
Do you take prescription opioid pain relievers for back pain and are you scheduled to have lumbar, thoracic, or cervical spine surgery? Are you 18-70? You may be able to take part in a research study to better understand how ketamine affects pain and opioid use after surgery. Eligible participants are scheduled for surgery with Dr. Okonkwo or Dr. Hamilton. Compensation will be provided.
A Sensorimotor Microelectrode Brain-Machine Interface
Do you have little or no ability to use your hands due to a cervical spinal cord injury, brainstem stroke, or spinal stroke? Are you aged 22-70? If so, you may be eligible to take part in a research study involving brain-machine interface (BMI) technology. BMI technology uses signals recorded from the brain to control devices such as a computer or a robotic limb. Compensation provided.
Remote Wheelchair Maintenance Training Program
Do you use a wheelchair as your primary means of mobility (over 40 hours a week) due to a traumatic spinal cord injury? If so, you may be interested in participating in a research study to find out if an online training program designed to teach people how to improve wheelchair maintenance techniques is effective. Compensation provided.
Restoring Sensation after Arm Amputation
Do you have an amputation of one or both arms? Are you between 18 and 70? If so, you may be able to take part in a research study designed to develop new technologies that may improve prosthetic (artificial limb) control and reduce phantom limb pain. Compensation provided.